William McK. Jefferies, MD. was an award-winning endocrinology research fellow at Harvard University in the late 1940s when the adrenal hormone cortisol (hydrocortisone) was discovered. From the start, it was obvious that hydrocortisone was amazingly effective at reversing the symptoms of such illnesses as rheumatoid arthritis. Unfortunately, the doctors soon found out that the huge doses that they used were highly toxic. For more information click here.