By William McK. Jefferies, M.D., F.A.C.P.
Second Edition published July,1996
© 1996 Charles C.Thomas·;Publisher,Ltd.
For ordering information: Please click on the publisher’s name above

ISBN 0-398-06620-5 (cloth)
ISBN 0-398-06621-3 (paper)
228 pages

The links below will redirect you the personal web pages of Dr. William McK. Jefferies. The copyright of the contents on these pages are owned by Dr. Jefferies and his heirs.

1. Homepage of Dr. William McK. Jefferies
2. Research Focus: “Cortisone: A Problem in Pharmaceutical Marketing
3. Safe Uses of Cortisol
4. A Continuation of the Cortisone Story: “Mild Adrenocortical Deficiency, Chronic Allergies, Autoimmune Disorders and the Chronic Fatigue Syndrome”
5. Low Dosage Glucocorticoid Therapy (Excerpts)
6. Reproduction of Dr. Jefferies Hydrocortisone Handout
7. Dr. Jefferies’ Reference Ranges for Serum Cortisol


Safe Uses of Cortisol

Success of the human body’s defenses against stress (injury, infection, fatigue) depends critically on the ability of the adrenal glands to produce appropriate amounts of the hormone, cortisol (hydrocortisone) the only hormone that is absolutely essential for life. It is a very dynamic hormone, with normal production and consumption fluctuating from minute to minute. Many people who have suffered from rheumatoid arthritis, or other autoimmune disorders, or from chronic allergic disorders such as hay fever or asthma, or from unexplained chronic fatigue (the chronic fatigue syndrome), as well as from infertility or other less severe disorders, have found that small, safe dosages of cortisol have been dramatically beneficial when prescribed by their physicians according to the author’s therapeutic recommendations.

A major revision of his work, Safe Uses of Cortisone, published in 1981, this Second Edition reviews the evidence that the ability of the adrenals to produce adequate amounts of cortisol in response to stress is a major factor in the maintenance of normal energy and health and it describes the diagnosis and treatment with safe, physiologic doses of this normal hormone in patients with mild adrenal deficiency, a condition that is not described in current medical textbooks but which may be present in many, if not all patients with the above disorders. The observations and recommendations are based on over 2,000 patient-years experience with the use of these safe physiologic doses. In the first 1,000 years of experience over 200 babies were born to women who were taking physiologic doses in order to correct infertility with no evidence of harm to either mothers or babies.